Charles C.N. Wang Ph.D

500, Lioufeng Rd., Wufeng, Taichung 41354, Taiwan · (04) 23323456#20053 ·

Dr. Charles C. N. Wang received his M.S. and Ph.D. degrees both in bioinformatics from Asia University, Taichung, Taiwan in 2008 and 2014. He is currently an associate professor with the department of bioinformatics, Asia University, Taichung, Taiwan. He is a data scientist with exhaustive experience in Bioinformatics, Semantic Computing, Natural Language Processing, and Machine Learning in several domains. He has published more than 50 academic research papers in various areas of semantic computing, text mining, natural language processing, and biomedical information. He is currently appointed as the section chief of development of AI Research Center and CEO of Center for Precision Medicine Research at Asia University. He is passionate about learning and always looks forward to solving challenging analytical problems.

Research Field:

Bioinformatics | Computational Biology | Systems Biology | Data Science in Biomedicine | Knowledge Discovery & Intelligent Computing |


Center for Precision Health Research


Asia University

Department of Bioinformatics and Medical Engineering

- Semantic Biomedical Intelligence and A Comparison of Models in Computational Systems Biology

September 2008 - June 2014

Asia University

Master of Science
Department of Bioinformatics

- The Establishment of A Rice Functional Genomics Information System in T-DNA Tagged Rice Service Center

September 2006 - June 2008



Industry-Academia Collaboration
2022 - Present


China Medical University - Asia University System Cloud Innovation School
2022 - Present


Center for Precision Medicine Research, Asia University
2020 - Present

Associate Professor

Department of Bioinformatics and Medical Engineering,Asia University

Bioinformatics | Computational Biology | Systems Biology | Data Science in Biomedicine | Knowledge Discovery & Intelligent Computing

2020 - Present

Section Chief of Development

Center for Artificial Intelligence, Asis University,Asia University
2018 - Present

Assistant Professor

Department of Bioinformatics and Medical Engineering,Asia University

Bioinformatics | Computational Biology | Systems Biology | Data Science in Biomedicine | Knowledge Discovery & Intelligent Computing

2019 - 2020

Exchange Research Scholar

University of California, Irvine, CA, US
2008 - 2013

Local Arrangement Chair

IEEE 2010 Summer School on Semantic Computing, Berkeley, CA, US
2009 and 2010



Association of epilepsy, anti-epileptic drugs (AEDs), and type 2 diabetes mellitus (T2DM): A population-based cohort retrospective study, impact of AEDs on T2DM-related molecular pathway, and via peroxisome proliferator-activated receptor gamma transactivation,Frontiers in Endocrinology (accepted)

TYMS and DTL are Prognostic Candidate Biomarkers of Cervical Cancer as Determined Using Gene Co-expression Network Analysis,IEEE ECBIOS 2023 (accepted)

Detect Acute Pulmonary Embolism on Non-contrast Computed Tomography Using Deep Learning Models,TWSC 2023 (accepted)

Chou, C. Y., Wang, C. C., , Chiang, H. Y., Huang, C. F., Hsiao, Y. L., Sun, C. H., ... & Kuo, C. C. (2023). Cardiothoracic ratio values and trajectories are associated with risk of requiring dialysis and mortality in chronic kidney disease. Communications Medicine, 3(1), 19.

Lai JW, Wang, C. C., , Chou CY (2023) Role of Tidal Peritoneal Dialysis in Urgent-start Peritoneal Dialysis. Int J Phys Med Rehabil. 11:662.


Charles C.N. Wang* , Tzu-TsenYu,andJeffrey J. P. TsaiA Model-Based Prognostic Predictor for Urothelial Bladder Carcinoma Through the Integrated Bioinformatics Analysis, IEEE BIBE 2022

Lin, C. W., Huang, H. Y., Guo, J. H., Chen, W. L., Shih, H. M., Chu, H. T., ... Hsu, T. & Wang, C.C.* (2022). Does Weekends Effect Exist in Asia? Analysis of Endovascular Thrombectomy for Acute Ischemic Stroke in A Medical Center. Current Neurovascular Research.

Cheng, D. C., Hsieh, T. C., Hsu, Y. J., Lai, Y. C., Yen, K. Y., Wang, C.C.* & Kao, C. H. (2022). Prediction of All-Cause Mortality Based on Stress/Rest Myocardial Perfusion Imaging (MPI) Using Deep Learning: A Comparison between Image and Frequency Spectra as Input. Journal of Personalized Medicine, 12(7), 1105.

Chen, D. L., Cai, J. H., & Wang, C.C.* (2022). Identification of Key Prognostic Genes of Triple Negative Breast Cancer by LASSO-Based Machine Learning and Bioinformatics Analysis. Genes, 13(5), 902.

Chang, Y. H., Shih, H. M., Wu, J. E., Huang, F. W., Chen, W. K., Cheng, D. M., ... & Wang, C. C. (2022). Machine learning–based triage to identify low-severity patients with a short discharge length of stay in emergency department.

Kok VC, Wang, C.C.*, Liao SH, Chen DL. Cross-Platform in-silico Analyses Exploring Tumor Immune Microenvironment with Prognostic Value in Triple-Negative Breast Cancer. Breast Cancer (Dove Med Press). 2022;14:85-99


Yu-Hsin Chang, Ying-Chen Lin, Wei-Kung Chen, Charles C.N. Wang (2021) Machine learning and natural language processing assisted triage for prediction of clinical disposition in emergency department, 2021 Asian Conference on Emergency Medicine (ACEM 2021)

Yu S-H, Cai J-H, Chen D-L, Liao S-H, Lin Y-Z, Chung Y-T, Tsai JJP, Wang CCN. LASSO and Bioinformatics Analysis in the Identification of Key Genes for Prognostic Genes of Gynecologic Cancer. Journal of Personalized Medicine. 2021; 11(11):1177.

King, E.K., Hsieh, MH., Chang, D.R.,Wang, C.C. et al. Prediction of non-responsiveness to pre-dialysis care program in patients with chronic kidney disease: a retrospective cohort analysis. Sci Rep 11, 13938 (2021).

Kung, R. Y., Pan, N. H., Wang, C.C., & Lee, P. C. (2021). Application of Deep Learning and Unmanned Aerial Vehicle on Building Maintenance. Advances in Civil Engineering, 2021.

Kok, V. C.,Wang, C.C., Liao, S. H., & Chen, D. L. (2021). Interleukin-17-based cytokine signaling as a determinant for tumor immune microenvironment with prognostic value in triple-negative breast cancer.


Tien, N., You, B. J., Lin, H. J., Chang, C. Y., Chou, C. Y., Lin, H. S.,Wang, C.C.& Chen, H. C. (2020). Repeated centrifuging and washing concentrates bacterial samples in peritoneal dialysis for optimal culture: an original article. BMC microbiology, 20(1), 1-9.

Chen, H. C., Lai, M. J., Wu, W. C., Lee, C. Y., Lin, H. J., Lin, Wang, C.C., & Chou, C. Y. (2020, October). Association of diabetes, education level, and care dependency with use of temporary vascular access in patients with chronic kidney disease. In Seminars in Dialysis.

Chang-Wei Hsieh, Yun-Ju Tsai, Corine Stefanie, Charles C.N. Wang, and Wen-Thong Chang (2020. November) The Preliminary Design of Water Quality Monitor System for the Ecological Pond based on LoRaWAN, IEEE International Symposium on Computer, Consumer and Control (IS3C 2020)

Wang, C.C., Jin, J., Chang, J. et al. Identification of most influential co-occurring gene suites for gastrointestinal cancer using biomedical literature mining and graph-based influence maximization. BMC Med Inform Decis Mak 20, 208 (2020).

Yang, J.-L., Wang, C.C.., Cai, J.-H., Chou, C.-Y., Lin, Y.-C., Hung, C.-C. (2020) Identification of GSN and LAMC2 as Key Prognostic Genes of Bladder Cancer by Integrated Bioinformatics Analysis. Cancers, 12, 1809.* Joint first author

Chang, Y. T., Lin, Y. C., Sun, L., Liao, W. C., Wang, C. C., Chou, C. Y., ... & Hung, C. C. (2020). Wilforine resensitizes multidrug resistant cancer cells via competitive inhibition of P-glycoprotein. Phytomedicine, 153239.

Lin, H. J., Sheu, P. C. Y., Tsai, J. J., Wang, C. C., & Chou, C. Y. (2020). Text mining in a literature review of urothelial cancer using topic model. BMC Cancer, 20(1), 1-7. * Joint first author

Li, C. Y., Cai, J. H., Tsai, J. J., & Wang, C. C. (2020). Identification of Hub Genes Associated with Development of Head and Neck Squamous Cell Carcinoma by Integrated Bioinformatics Analysis. Frontiers in Oncology, 10, 681.

Teng, Y. N., Wang, C. C., Liao, W. C., Lan, Y. H., & Hung, C. C. (2020). Caffeic Acid Attenuates Multi-Drug Resistance in Cancer Cells by Inhibiting Efflux Function of Human P-glycoprotein. Molecules, 25(2), 247.


Tai, T. S., Tien, N., Shen, H. Y., Chu, F. Y., Wang, C. C., Lu, C. H., ... & Chang, H. Y. (2019). Sesamin, a Naturally Occurring Lignan, Inhibits Ligand-Induced Lipogenesis through Interaction with Liver X Receptor Alpha (LXRα) and Pregnane X Receptor (PXR). Evidence-Based Complementary and Alternative Medicine, 2019.

Lin, H.C., Wu J.E. & Wang, C. C.(2019, October)A Smartphone App to Neonatal Jaundice Detection using Deep Learning Model, The First International Symposium on Future ICT (Future ICT 2019)

Wong, J.K., Lin, Y.Z., Tsai, J.J. & Wang, C. C. (2019, October)Machine Learning Classification Algorithms on Treadmill Exercise Data for Predicting Significant Coronary Artery Disease, The First International Symposium on Future ICT (Future ICT 2019) *Best Paper Awards

Chen, C. Y., Lin, Y. J., Wang, C. C., Lan, Y. H., Lan, S. J., & Sheu, M. J. (2019). Epigallocatechin-3-gallate inhibits tumor angiogenesis: involvement of endoglin/Smad1 signaling in human umbilical vein endothelium cells. Biomedicine & Pharmacotherapy, 120, 109491.

Chang, Y. T., Teng, Y. N., Lin, K. I., Wang, C. C., Morris-Natschke, S. L., Lee, K. H., & Hung, C. C. (2019). Danazol mediates collateral sensitivity via STAT3/Myc related pathway in multidrug-resistant cancer cells. Scientific reports, 9(1), 1-11.

Wang, C. C., Li, C.Y., Cai, J.-H., Sheu, P.-Y., Tsai, J.J., Wu, M.-Y., Li, C.-J., Hou, M.-F. (2019) Identification of Prognostic Candidate Genes in Breast Cancer by Integrated Bioinformatic Analysis. J. Clin. Med. 8, 1160.


Chen, H. J., Chung, Y. L., Li, C. Y., Chang, Y. T., Wang, C. C., Lee, H. Y., ... & Hung, C. C. (2018). Taxifolin Resensitizes Multidrug Resistance Cancer Cells via Uncompetitive Inhibition of P-Glycoprotein Function. Molecules, 23(12), 3055.

Wang, C. C., Chang, P. C., Sheu, P. C., & Tsai, J. J. Computational Modeling of the Early Development of Embryonic Leaves in Maize. In Bioinformatics and Bioengineering (BIBE), 2018 IEEE 18th International Conference on (pp. 352-355). IEEE.

Lin, Y.N., Wang, C. C., Chang H.Y., Chu F.Y., Hsu Y.A., Cheng W.K., Ma W.C., Chen C.J., Wan L., Lim Y.P. (2018). Ursolic Acid, a Novel Liver X Receptor α (LXRα) Antagonist Inhibiting Ligand-Induced Nonalcoholic Fatty Liver and Drug-Induced Lipogenesis.Journal of Agricultural and Food Chemistry. * Joint first author

Lin, Y. N., Chang, H. Y., Wang, C. C., Chu, F. Y., Shen, H. Y., Chen, C. J., & Lim, Y. P. (2018). Oleanolic Acid Inhibits Liver X Receptor Alpha and Pregnane X Receptor to Attenuate Ligand-Induced Lipogenesis. Journal of Agricultural and Food Chemistry. * Joint first author

Wang, C. C., Chung , Y. L., Chang, I. S., & Tsai, J. J. (2018). A Semantic Recommendation System for Cancer Related Articles. Encyclopedia with Semantic Computing and Robotic Intelligence.

Chang, Y. T.,Wang, C. C. , Wang, J. Y., Lee, T. E., Cheng, Y. Y., Morris-Natschke, S. L., ... & Hung, C. C. (2018). Tenulin and isotenulin inhibit P-glycoprotein function and overcome multidrug resistance in cancer cells. Phytomedicine.

Lin, C. Y., Hung, C. C., Wang, C. C., Lin, H. Y., Huang, S. H., & Sheu, M. J. (2018). Demethoxycurcumin sensitizes the response of non-small cell lung cancer to cisplatin through downregulation of TP and ERCC1-related pathways. Phytomedicine.

Li, Y. W., Wang, C. H., Chen, C. J., Wang, C. C., Lin, C. L., Cheng, W. K., ... & Lim, Y. P. (2018). Effects of antiepileptic drugs on lipogenic gene regulation and hyperlipidemia risk in Taiwan: a nationwide population-based cohort study and supporting in vitro studies. Archives of toxicology, 1-16.

Wang, C. C., Chang, I. S., Sheu, P. C., & Tsai, J. J. (2018, January). Application of Semantic Computing in Cancer on Secondary Data Analysis. In 2018 Second IEEE International Conference on Robotic Computing (IRC) (pp. 407-412). IEEE.


Wang, C. C., & Tsai, J. J. (2017). Use of semantics in bio-informatics. Encyclopedia with Semantic Computing and Robotic Intelligence, 1(01), 1630017.

Wang, C. C., & Tsai, J. J. (2017). Use of semantics in bio-informatics. In Edited by: Phillip C-Y Sheu, Semantic Computing. pp. 191-195. US

Wang, C. C., Sheu, P. C., & Tsai, J. J.(2017). Semantic analytics of biomedical data. In Edited by: Jeffrey J P Tsai & Ka-Lok Ng. Computational Methods with Applications in Bioinformatics Analysis. pp. 72-97. US

Hung, D. Z., Tien, N., Lin, C. L., Lee, Y. R., Wang, C. C., Chen, J. J., & Lim, Y. P. (2017). Increased risk of chronic osteomyelitis after hip replacement: a retrospective population-based cohort study in an Asian population. European Journal of Clinical Microbiology & Infectious Diseases, 36(4), 611-617.


Wang, C. C., Chang, P. C., Sheu, P. C., & Tsai, J. J. (2016, October). A Comparison Study of Reverse Engineering Gene Regulatory Network Modeling. In Bioinformatics and Bioengineering (BIBE), 2016 IEEE 16th International Conference on (pp. 356-362). IEEE.

Wang, C. C., Lee, Y. L., Sheu, P. C., & Tsai, J. J. (2016, October). Application of Latent Semantic Analysis to Clustering of Cardiovascular Gene Ontology. In Bioinformatics and Bioengineering (BIBE), 2016 IEEE 16th International Conference on (pp. 363-368). IEEE.

Wang, J. D., Chan, W. L., Wang, C. C., Chang, J. G., & Tsai, J. J. (2016, October). Mining distinctive DNA patterns from the upstream of human coding&non-coding genes via class frequency distribution. In Computational Intelligence in Bioinformatics and Computational Biology (CIBCB), 2016 IEEE Conference on (pp. 1-6). IEEE.

Hung, D. Z., Lin, C. L., Li, Y. W., Lin, Y. N., Lee, Y. R., Wang, C. C., ... & Lim, Y. P. (2016). Association between antiepileptic drugs and hepatocellular carcinoma in patients with epilepsy: a population‐based case–control study. Brain and behavior, 6(11).

Chung, Y. L., Pan, C. H., Wang, C. C., Hsu, K. C., Sheu, M. J., Chen, H. F., & Wu, C. H. (2016). Methyl Protodioscin, a Steroidal Saponin, Inhibits Neointima Formation in Vitro and in Vivo. Journal of natural products, 79(6), 1635-1644.


Wang, C. C., Sheu, P. C. Y., & Tsai, J. J. (2015). Towards Semantic Biomedical Problem Solving. International Journal of Semantic Computing, 9(04), 415-431.


Wang, C. C., Chang, P. C., Ng, K. L., Chang, C. M., Sheu, P. C., & Tsai, J. J. (2014). A model comparison study of the flowering time regulatory network in Arabidopsis. BMC systems biology, 8(1), 15.


Wang, C. C., Hecht, D. A., Sheu, P. C. Y., & Tsai, J. J. (2013, September). Semantic computing and drug discovery-a preliminary report. In Semantic Computing (ICSC), 2013 IEEE Seventh International Conference on (pp. 453-458). IEEE.

Tai, W. L., Wang, C. C., Sheu, P. C., & Tsai, J. J. (2013). Data hiding in DNA for authentication of plant variety rights. Journal of Electronic Science and Technology, 11(1), 38-43.

Academic Society

  • 台灣生物資訊與系統生物學會/International Conference on Genome Informatics
  • 台灣雲端計算學會/Taiwan Association of Cloud Computing