Charles C.N. Wang Ph.D

500, Lioufeng Rd., Wufeng, Taichung 41354, Taiwan · (04) 23323456#20053 · cnwang@asia.edu.tw

Dr. Charles C. N. Wang received his M.S. and Ph.D. degrees both in bioinformatics from Asia University, Taichung, Taiwan in 2008 and 2014. He is currently an associate professor with the department of bioinformatics, Asia University, Taichung, Taiwan. He is a data scientist with exhaustive experience in Bioinformatics, Semantic Computing, Natural Language Processing, and Machine Learning in several domains. He has published more than 50 academic research papers in various areas of semantic computing, text mining, natural language processing, and biomedical information. He is currently appointed as the section chief of development of AI Research Center and CEO of Center for Precision Medicine Research at Asia University. He is passionate about learning and always looks forward to solving challenging analytical problems.

Research Field:

Bioinformatics | Semantic Computing | Deep Learning | Natural Language Understanding | Knowledge Discovery

Lab:

Center for Precision Medicine Research

Education

Asia University

PhD
Department of Bioinformatics and Medical Engineering

- Semantic Biomedical Intelligence and A Comparison of Models in Computational Systems Biology

September 2008 - June 2014

Asia University

M.S
Department of Bioinformatics

- The Establishment of A Rice Functional Genomics Information System in T-DNA Tagged Rice Service Center

September 2006 - June 2008

Experience

CEO

Center for Precision Medicine Research, Asia University
2020 - Present

Associate Professor

Department of Bioinformatics and Medical Engineering,Asia University

Bioinformatics| Systems Biology | Semantic Computing | Text Mining | Knowledge Discovery

2020 - Present

Section Chief of Development

Center for Artificial Intelligence, Asis University,Asia University
2018 - Present

Assistant Professor

Department of Bioinformatics and Medical Engineering,Asia University

Bioinformatics| Systems Biology | Semantic Computing | Text Mining | Knowledge Discovery

2018 - 2020

Exchange Research Scholar

University of California, Irvine, CA, US
2008 - 2013

Local Arrangement Chair

IEEE 2010 Summer School on Semantic Computing, Berkeley, CA, US
2009 and 2010

Publications

2021

Victor C. Kok, Charles C.N. Wang, Szu-Han Liao, De-Lun Chen(2021) Interleukin-17 and cytokine-related signalings are determinants for tumor immune microenvironment in triple-negative breast cancer: in silico integrated analysis.AACR 2021 (accepted)

2020

Tien, N., You, B. J., Lin, H. J., Chang, C. Y., Chou, C. Y., Lin, H. S., Wang, C.C., & Chen, H. C. (2020). Repeated centrifuging and washing concentrates bacterial samples in peritoneal dialysis for optimal culture: an original article. BMC microbiology, 20(1), 1-9.

Chen, H. C., Lai, M. J., Wu, W. C., Lee, C. Y., Lin, H. J., Lin, Wang, C.C., & Chou, C. Y. (2020, October). Association of diabetes, education level, and care dependency with use of temporary vascular access in patients with chronic kidney disease. In Seminars in Dialysis.

Chang-Wei Hsieh, Yun-Ju Tsai, Corine Stefanie, Charles C.N. Wang, and Wen-Thong Chang (2020. November) The Preliminary Design of Water Quality Monitor System for the Ecological Pond based on LoRaWAN, IEEE International Symposium on Computer, Consumer and Control (IS3C 2020)

Wang, C.C., Jin, J., Chang, J. et al. Identification of most influential co-occurring gene suites for gastrointestinal cancer using biomedical literature mining and graph-based influence maximization. BMC Med Inform Decis Mak 20, 208 (2020).

Yang, J.-L., Wang, C.C.., Cai, J.-H., Chou, C.-Y., Lin, Y.-C., Hung, C.-C. (2020) Identification of GSN and LAMC2 as Key Prognostic Genes of Bladder Cancer by Integrated Bioinformatics Analysis. Cancers, 12, 1809.* Joint first author

Chang, Y. T., Lin, Y. C., Sun, L., Liao, W. C., Wang, C. C., Chou, C. Y., ... & Hung, C. C. (2020). Wilforine resensitizes multidrug resistant cancer cells via competitive inhibition of P-glycoprotein. Phytomedicine, 153239.

Lin, H. J., Sheu, P. C. Y., Tsai, J. J., Wang, C. C., & Chou, C. Y. (2020). Text mining in a literature review of urothelial cancer using topic model. BMC Cancer, 20(1), 1-7. * Joint first author

Li, C. Y., Cai, J. H., Tsai, J. J., & Wang, C. C. (2020). Identification of Hub Genes Associated with Development of Head and Neck Squamous Cell Carcinoma by Integrated Bioinformatics Analysis. Frontiers in Oncology, 10, 681.

Teng, Y. N., Wang, C. C., Liao, W. C., Lan, Y. H., & Hung, C. C. (2020). Caffeic Acid Attenuates Multi-Drug Resistance in Cancer Cells by Inhibiting Efflux Function of Human P-glycoprotein. Molecules, 25(2), 247.

2019

Tai, T. S., Tien, N., Shen, H. Y., Chu, F. Y., Wang, C. C., Lu, C. H., ... & Chang, H. Y. (2019). Sesamin, a Naturally Occurring Lignan, Inhibits Ligand-Induced Lipogenesis through Interaction with Liver X Receptor Alpha (LXRα) and Pregnane X Receptor (PXR). Evidence-Based Complementary and Alternative Medicine, 2019.

Lin, H.C., Wu J.E. & Wang, C. C.(2019, October)A Smartphone App to Neonatal Jaundice Detection using Deep Learning Model, The First International Symposium on Future ICT (Future ICT 2019)

Wong, J.K., Lin, Y.Z., Tsai, J.J. & Wang, C. C. (2019, October)Machine Learning Classification Algorithms on Treadmill Exercise Data for Predicting Significant Coronary Artery Disease, The First International Symposium on Future ICT (Future ICT 2019) *Best Paper Awards

Chen, C. Y., Lin, Y. J., Wang, C. C., Lan, Y. H., Lan, S. J., & Sheu, M. J. (2019). Epigallocatechin-3-gallate inhibits tumor angiogenesis: involvement of endoglin/Smad1 signaling in human umbilical vein endothelium cells. Biomedicine & Pharmacotherapy, 120, 109491.

Chang, Y. T., Teng, Y. N., Lin, K. I., Wang, C. C., Morris-Natschke, S. L., Lee, K. H., & Hung, C. C. (2019). Danazol mediates collateral sensitivity via STAT3/Myc related pathway in multidrug-resistant cancer cells. Scientific reports, 9(1), 1-11.

Wang, C. C., Li, C.Y., Cai, J.-H., Sheu, P.-Y., Tsai, J.J., Wu, M.-Y., Li, C.-J., Hou, M.-F. (2019) Identification of Prognostic Candidate Genes in Breast Cancer by Integrated Bioinformatic Analysis. J. Clin. Med. 8, 1160.

2018

Chen, H. J., Chung, Y. L., Li, C. Y., Chang, Y. T., Wang, C. C., Lee, H. Y., ... & Hung, C. C. (2018). Taxifolin Resensitizes Multidrug Resistance Cancer Cells via Uncompetitive Inhibition of P-Glycoprotein Function. Molecules, 23(12), 3055.

Wang, C. C., Chang, P. C., Sheu, P. C., & Tsai, J. J. Computational Modeling of the Early Development of Embryonic Leaves in Maize. In Bioinformatics and Bioengineering (BIBE), 2018 IEEE 18th International Conference on (pp. 352-355). IEEE.

Lin, Y.N., Wang, C. C., Chang H.Y., Chu F.Y., Hsu Y.A., Cheng W.K., Ma W.C., Chen C.J., Wan L., Lim Y.P. (2018). Ursolic Acid, a Novel Liver X Receptor α (LXRα) Antagonist Inhibiting Ligand-Induced Nonalcoholic Fatty Liver and Drug-Induced Lipogenesis.Journal of Agricultural and Food Chemistry. * Joint first author

Lin, Y. N., Chang, H. Y., Wang, C. C., Chu, F. Y., Shen, H. Y., Chen, C. J., & Lim, Y. P. (2018). Oleanolic Acid Inhibits Liver X Receptor Alpha and Pregnane X Receptor to Attenuate Ligand-Induced Lipogenesis. Journal of Agricultural and Food Chemistry. * Joint first author

Wang, C. C., Chung , Y. L., Chang, I. S., & Tsai, J. J. (2018). A Semantic Recommendation System for Cancer Related Articles. Encyclopedia with Semantic Computing and Robotic Intelligence.

Chang, Y. T.,Wang, C. C. , Wang, J. Y., Lee, T. E., Cheng, Y. Y., Morris-Natschke, S. L., ... & Hung, C. C. (2018). Tenulin and isotenulin inhibit P-glycoprotein function and overcome multidrug resistance in cancer cells. Phytomedicine.

Lin, C. Y., Hung, C. C., Wang, C. C., Lin, H. Y., Huang, S. H., & Sheu, M. J. (2018). Demethoxycurcumin sensitizes the response of non-small cell lung cancer to cisplatin through downregulation of TP and ERCC1-related pathways. Phytomedicine.

Li, Y. W., Wang, C. H., Chen, C. J., Wang, C. C., Lin, C. L., Cheng, W. K., ... & Lim, Y. P. (2018). Effects of antiepileptic drugs on lipogenic gene regulation and hyperlipidemia risk in Taiwan: a nationwide population-based cohort study and supporting in vitro studies. Archives of toxicology, 1-16.

Wang, C. C., Chang, I. S., Sheu, P. C., & Tsai, J. J. (2018, January). Application of Semantic Computing in Cancer on Secondary Data Analysis. In 2018 Second IEEE International Conference on Robotic Computing (IRC) (pp. 407-412). IEEE.

2017

Wang, C. C., & Tsai, J. J. (2017). Use of semantics in bio-informatics. Encyclopedia with Semantic Computing and Robotic Intelligence, 1(01), 1630017.

Wang, C. C., & Tsai, J. J. (2017). Use of semantics in bio-informatics. In Edited by: Phillip C-Y Sheu, Semantic Computing. pp. 191-195. US

Wang, C. C., Sheu, P. C., & Tsai, J. J.(2017). Semantic analytics of biomedical data. In Edited by: Jeffrey J P Tsai & Ka-Lok Ng. Computational Methods with Applications in Bioinformatics Analysis. pp. 72-97. US

Hung, D. Z., Tien, N., Lin, C. L., Lee, Y. R., Wang, C. C., Chen, J. J., & Lim, Y. P. (2017). Increased risk of chronic osteomyelitis after hip replacement: a retrospective population-based cohort study in an Asian population. European Journal of Clinical Microbiology & Infectious Diseases, 36(4), 611-617.

2016

Wang, C. C., Chang, P. C., Sheu, P. C., & Tsai, J. J. (2016, October). A Comparison Study of Reverse Engineering Gene Regulatory Network Modeling. In Bioinformatics and Bioengineering (BIBE), 2016 IEEE 16th International Conference on (pp. 356-362). IEEE.

Wang, C. C., Lee, Y. L., Sheu, P. C., & Tsai, J. J. (2016, October). Application of Latent Semantic Analysis to Clustering of Cardiovascular Gene Ontology. In Bioinformatics and Bioengineering (BIBE), 2016 IEEE 16th International Conference on (pp. 363-368). IEEE.

Wang, J. D., Chan, W. L., Wang, C. C., Chang, J. G., & Tsai, J. J. (2016, October). Mining distinctive DNA patterns from the upstream of human coding&non-coding genes via class frequency distribution. In Computational Intelligence in Bioinformatics and Computational Biology (CIBCB), 2016 IEEE Conference on (pp. 1-6). IEEE.

Hung, D. Z., Lin, C. L., Li, Y. W., Lin, Y. N., Lee, Y. R., Wang, C. C., ... & Lim, Y. P. (2016). Association between antiepileptic drugs and hepatocellular carcinoma in patients with epilepsy: a population‐based case–control study. Brain and behavior, 6(11).

Chung, Y. L., Pan, C. H., Wang, C. C., Hsu, K. C., Sheu, M. J., Chen, H. F., & Wu, C. H. (2016). Methyl Protodioscin, a Steroidal Saponin, Inhibits Neointima Formation in Vitro and in Vivo. Journal of natural products, 79(6), 1635-1644.

2015

Wang, C. C., Sheu, P. C. Y., & Tsai, J. J. (2015). Towards Semantic Biomedical Problem Solving. International Journal of Semantic Computing, 9(04), 415-431.

2014

Wang, C. C., Chang, P. C., Ng, K. L., Chang, C. M., Sheu, P. C., & Tsai, J. J. (2014). A model comparison study of the flowering time regulatory network in Arabidopsis. BMC systems biology, 8(1), 15.

2013

Wang, C. C., Hecht, D. A., Sheu, P. C. Y., & Tsai, J. J. (2013, September). Semantic computing and drug discovery-a preliminary report. In Semantic Computing (ICSC), 2013 IEEE Seventh International Conference on (pp. 453-458). IEEE.

Tai, W. L., Wang, C. C., Sheu, P. C., & Tsai, J. J. (2013). Data hiding in DNA for authentication of plant variety rights. Journal of Electronic Science and Technology, 11(1), 38-43.

Resource

  • Chatbot

    Chatbots, also called Conversational Agents or Dialog Systems, are a hot topic. Microsoft is making big bets on chatbots, and so are companies like Facebook (M), Apple (Siri), Google, WeChat, and Slack.